Tumor Suppressor Genes and Cancer

Tumor Suppressor Genes and Cancer

Cancer, Specialized Topics

Last Updated: September 12, 2025 Introduction to Tumor Suppressor Genes Tumor suppressor genes were first identified by making cell hybrids between tumor and normal cells. On some occasions a chromosome from the normal cell reverted the transformed phenotype. Several...
Proto-Oncogenes and Cancer

Proto-Oncogenes and Cancer

Cancer, Specialized Topics

Last Updated: October 31, 2025 Introduction to Proto-oncogenes Most, if not all, cancer cells contain genetic damage that appears to be the responsible event leading to tumorigenesis. The genetic damage present in a parental tumorigenic cell is maintained (i.e. not...