Hemostasis: Blood Coagulation, Specialized Topics
Last Updated: Octonber 23, 2025 Introduction to Blood Coagulation The ability of the body to control the flow of blood following vascular injury is paramount to continued survival. The process of blood coagulation (clotting) and then the subsequent dissolution of the...
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to von Willebrand Disease von Willebrand disease (vWD) is caused by deficiencies in the protein von Willebrand factor (vWF). vWF is a multi-subunit glycoprotein that is found in subendothelial connective tissue,...
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Glanzmann Thrombasthenia Glanzmann thrombasthenia (weak platelets) is an autosomal recessive disorder affecting the processes of blood coagulation that was originally described in 1918 by the Swiss pediatrician W.E....
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Protein C Protein C (PC) is a trypsin-like serine protease that serves as a major regulator of the blood coagulation process. Protein S (PS) serves as a co-factor for the functions of activated protein C (abbreviated aPC,...
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Factor XIII Factor XIII is also called protransglutaminase, fibrin stabilizing factor (FSF), and fibrinoligase. Factor XIII is found both in the plasma and in platelets. The plasma version is a heterodimeric enzyme...
