Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to von Willebrand Disease von Willebrand disease (vWD) is caused by deficiencies in the protein von Willebrand factor (vWF). vWF is a multi-subunit glycoprotein that is found in subendothelial connective tissue,...
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Glanzmann Thrombasthenia Glanzmann thrombasthenia (weak platelets) is an autosomal recessive disorder affecting the processes of blood coagulation that was originally described in 1918 by the Swiss pediatrician W.E....
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Protein C Protein C (PC) is a trypsin-like serine protease that serves as a major regulator of the blood coagulation process. Protein S (PS) serves as a co-factor for the functions of activated protein C (abbreviated aPC,...
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Factor XIII Factor XIII is also called protransglutaminase, fibrin stabilizing factor (FSF), and fibrinoligase. Factor XIII is found both in the plasma and in platelets. The plasma version is a heterodimeric enzyme...
Diseases and Disorders, Disorders of Coagulation Factors
Last Updated: October 28, 2025 Introduction to Factor XII Factor XII is also know, historically, as Hageman factor. Factor XII is involved in the activation of the intrinsic coagulation cascade. The intrinsic coagulation cascade is activated by contact of a complex...
