Cancer, Specialized Topics
Last Updated: September 12, 2025 Introduction to Tumor Suppressor Genes Tumor suppressor genes were first identified by making cell hybrids between tumor and normal cells. On some occasions a chromosome from the normal cell reverted the transformed phenotype. Several...
Cancer, Specialized Topics
Last Updated: October 31, 2025 Introduction to Proto-oncogenes Most, if not all, cancer cells contain genetic damage that appears to be the responsible event leading to tumorigenesis. The genetic damage present in a parental tumorigenic cell is maintained (i.e. not...
Cancer, Diseases and Disorders, Diseases Associated with DNA Abnormalities, DNA Repair Disorders
Last Updated: October 31, 2025 BRCA1 Gene and Protein Functions The BReast CAncer 1, early onset gene (BRCA1) which encodes the breast cancer type 1 susceptibility protein was originally identified in 1994 as a causative gene in hereditary breast and ovarian cancers....
