The mucopolysaccharidoses (MPS) constitute a family of lysosomal storage diseases characterized by deficiencies in lysosomal hydrolases responsible for the degradation of glycosaminoglycans (historically called mucopolysaccharides). All of the MPS diseases are chronic progressively debilitating disorders that in many instances lead to severe psychomotor retardation and premature death. In addition, the clinical spectrum of these disorders can vary widely within one enzyme deficiency.
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Michael W. King, Ph.D / IU School of Medicine / miking at iupui.edu